2026

Telomere Dysfunction in Human Astrocytes Drives Acrocentric Chromosome Instability and Nucleolar Reorganization

Mbegbu et al. 2026. bioRxiv.

KaryoScope: rapid, alignment-free sequence annotation for the pangenome era

Ranallo-Benavidez et al. 2026. bioRxiv.

A complete human pancreatic cancer genome

Wagner et al. 2026. bioRxiv.

Single-molecule variation in telomeric sequence and structure across humans

Dubocanin et al. 2026. bioRxiv.

Haplotype-resolved genome assemblies of BJ and IMR-90 human fibroblast cell lines reveal extensive structural variation and enable reanalysis of historical sequencing data

Ranallo-Benavidez et al. 2026. NAR.

Chromosome-arm-specific telomere length governs dual modes of structural genome evolution in IDH-mutant astrocytoma

Jehangir et al. 2026. bioRxiv.

2025

Accurate somatic small variant discovery for multiple sequencing technologies with DeepSomatic

Park et al. 2025. Nature Biotechnology.

Uncommon Territory: The Clinical and Molecular Profile of Metastatic Gliomas

Barthel. 2025. Neuro-Oncology.

Mapping the Telomeric 3D Interactome with Telomere-C Reveals Repetitive Element Hubs Associated with Telomere Maintenance

Chen et al. 2025. bioRxiv.

Cell-Free DNA Sequencing Uncovers the Longitudinal Consequences of Temozolomide Treatment and Host Co-Culture in Glioblastoma

Mankame et al. 2025. bioRxiv.

2024

The epigenetic evolution of glioma is determined by the IDH1 mutation status and treatment regimen

Malta et al. 2024. Cancer Res.

2023

Anaplerotic nutrient stress drives synergy of angiogenesis inhibitors with therapeutics targeting tumor metabolism

2022

PDPN marks a subset of aggressive and radiation-resistant glioblastoma cells

Modrek et al. 2022. Frontiers in Oncology.

Glioma progression is shaped by genetic evolution and microenvironment interactions

Varn et al. 2022. Cell.

The Molecular Anatomy of Diffuse Gliomas in Adults

2021

Single-cell multimodal glioma analyses identify epigenetic regulators of cellular plasticity and environmental stress response

Johnson et al. 2021. Nat Genet.

Spatial concordance of DNA methylation classification in diffuse glioma

Verburg et al. 2021. Neuro-Oncology

Radiotherapy is associated with a deletion signature that contributes to poor outcomes in patients with cancer

Kocakavuk et al. 2021. Nat Genet.

2020

Glioblastoma in adults: a Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions

Wen et al. 2020. Neuro Oncol.

Comparative Molecular Life History of Spontaneous Canine and Human Gliomas

Amin et al. 2020. Cancer Cell.

Molecular and clonal evolution in recurrent metastatic gliosarcoma

Anderson et al. 2019. Cold Spring Harb Mol Case Stud.

2019

Longitudinal molecular trajectories of diffuse glioma in adults

Barthel et al. 2019. Nature.

2018

Evolving Insights into the Molecular Neuropathology of Diffuse Gliomas in Adults

Barthel et al. 2018. Neurol Clin.

The Tandem Duplicator Phenotype Is a Prevalent Genome-Wide Cancer Configuration Driven by Distinct Gene Mutations

Menghi et al. 2018. Cancer Cell.

Reconstructing the molecular life history of gliomas

Barthel et al. 2018. Acta Neuropathol.

TumorFusions: an integrative resource for cancer-associated transcript fusions

Hu et al. 2018. Nucleic Acids Res.

2017

Comprehensive and Integrated Genomic Characterization of Adult Soft Tissue Sarcomas

Cancer Genome Atlas Research Network. 2017. Cell.

Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment

Wang et al. 2017. Cancer Cell.

Multigene signature for predicting prognosis of patients with 1p19q co-deletion diffuse glioma

Hu et al. 2017. Neuro Oncol.

Systematic analysis of telomere length and somatic alterations in 31 cancer types

Barthel et al. 2017. Nat Genet.

2016

Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma

Ceccarelli, Barthel, Malta, Sabedot et al. 2016. Cell.