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Floris Barthel
Principal investigator

As an Assistant Professor at the Cancer and Cell Biology Division at the Translational Genomics Institute (TGen) and the Department of Computational and Quantitative Medicine (DCQM) at the Beckman Research Institute (BRI) at City of Hope (COH), I lead a basic and translational research program utilizing state-of-the-art genomic approaches to study the development and evolution of glial brain tumors (gliomas). I am a full program member of City of Hope’s Comprehensive Cancer Center affiliated with the Molecular and Cellular Biology of Cancer (MCBC) program. My lab has a particular interest in the fundamental role of telomere dysfunction in glioma development, but is generally interested in all aspects of tumor evolution, including, but not limited to, longitudinal studies of therapy response assessed by genomic analysis of tumor tissue and liquid biopsies. The lab has received both public and private philanthropic funding for several translational and basic science research projects in this domain.

My medical and postdoctoral training have given me a broad, fundamental understanding of pathology, molecular biology, genetics and computational biology. My post-doctoral work in the group of Dr. Roel Verhaak aimed to define the molecular makeup of adult glial brain tumors in order to refine the taxonomy of disease and discover new therapeutic vulnerabilities. Using high-throughput sequencing and computational analysis I redefined the set of genes associated with diffuse glioma, used molecular profiling to enhance the resolution with which these tumors could be classified, and provided insights into the progression from low- to high-grade cancer. My work played a small role in the 2016 revision and 2021 edition of the internationally accepted World Health Organization guidelines for the classification of brain tumors.


PDPN marks a subset of aggressive and radiation-resistant glioblastoma cells

Glioma progression is shaped by genetic evolution and microenvironment interactions

Single-cell multimodal glioma analyses identify epigenetic regulators of cellular plasticity and environmental stress response

Spatial concordance of DNA methylation classification in diffuse glioma

Radiotherapy is associated with a deletion signature that contributes to poor outcomes in patients with cancer

Glioblastoma in adults: a Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions

Comparative Molecular Life History of Spontaneous Canine and Human Gliomas

Molecular and clonal evolution in recurrent metastatic gliosarcoma

Longitudinal molecular trajectories of diffuse glioma in adults

Evolving Insights into the Molecular Neuropathology of Diffuse Gliomas in Adults

The Tandem Duplicator Phenotype Is a Prevalent Genome-Wide Cancer Configuration Driven by Distinct Gene Mutations

Reconstructing the molecular life history of gliomas

TumorFusions: an integrative resource for cancer-associated transcript fusions

Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment

Multigene signature for predicting prognosis of patients with 1p19q co-deletion diffuse glioma

Systematic analysis of telomere length and somatic alterations in 31 cancer types

Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma


Let's go Diamondbacks!

CSHL telomere meeting

One year anniversary lab lunch

CSHL Brain Tumor Course

Lab photos

Lab Dinner at Pemberton

Floris awarded ASCI award

Sylvia Chase Early Career Training Program

First day at the new lab

Featured on the cover of Nature Genetics

Genomics of Cancer Radiotherapy published in Nature Genetics!

Awarded Forbeck COVID recovery award

Riya joins the team

Hello, World!