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Floris Barthel
Principal investigator

I am an Assistant Professor at the Cancer and Cell Biology Division at the Translational Genomics Institute (TGen) and the Department of Computational and Quantitative Medicine (DCQM) at the Beckman Research Institute (BRI) at City of Hope (COH). I did my postdoc in the laboratory of Roel Verhaak at the MD Anderson Cancer Center and later at the Jackson Laboratory where I studied the molecular makeup of glial brain tumors. During these years, I published first-author papers in top-tier journals including Nature and Cell, and perhaps more importantly, my work played a small part in recent updates to the World Health Organization guidelines for the classification of brain tumors.

My ongoing research aims to dissect the role of telomere dysfunction in gliomagenesis using high-throughput sequencing and computational analysis. I will determine the mutational signatures of telomere dysfunction and provide an accurate picture of the role of this process in shaping cancer genomes. Supported by a K99/R00 transitional award from the National Cancer Institute I am funded to interrogate the strategies of telomere maintenance in cancer cells. My recent awards include being named a Forbeck Scholar by the William Guy Forbeck Research Foundation and being awarded the Research Rising Star Award by the Brain Tumor Charity.


Single-cell multimodal glioma analyses identify epigenetic regulators of cellular plasticity and environmental stress response

Spatial concordance of DNA methylation classification in diffuse glioma

Radiotherapy is associated with a deletion signature that contributes to poor outcomes in patients with cancer

Glioblastoma in adults: a Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions

Comparative Molecular Life History of Spontaneous Canine and Human Gliomas

Molecular and clonal evolution in recurrent metastatic gliosarcoma

Longitudinal molecular trajectories of diffuse glioma in adults

Evolving Insights into the Molecular Neuropathology of Diffuse Gliomas in Adults

The Tandem Duplicator Phenotype Is a Prevalent Genome-Wide Cancer Configuration Driven by Distinct Gene Mutations

Reconstructing the molecular life history of gliomas

TumorFusions: an integrative resource for cancer-associated transcript fusions

Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment

Multigene signature for predicting prognosis of patients with 1p19q co-deletion diffuse glioma

Systematic analysis of telomere length and somatic alterations in 31 cancer types

Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma


Lab Dinner at Pemberton

Floris awarded ASCI award

Sylvia Chase Early Career Training Program

First day at the new lab

Featured on the cover of Nature Genetics

Genomics of Cancer Radiotherapy published in Nature Genetics!

Awarded Forbeck COVID recovery award

Riya joins the team

Hello, World!